This Startup Will Pay For Your Speeding Ticket–If It Can’t Get it Dismissed. It’s the Best Marketing I’ve Seen The must-know strategy behind the clever campaign. Continued here |
Rethink Your Employee Value Proposition A lot of leaders believe that the formula for attracting and keeping talent is simple: Just ask people what they want and give it to them. The problem is, that approach tends to address only the material aspects of jobs that are top of employees’ minds at the moment, like pay or flexibility. And those offerings are easy for rivals to imitate and have the least enduring impact on retention. Companies instead should focus on what workers need to thrive over the long term, balancing material offerings with opportunities to grow, connection and community, and meaning and purpose. Continued here |
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Earth’s most abundant organic material provides an ion highway Illustration of cellulose molecules (red and grey) form channels that carry water molecules (teal) and sodium ions (violet). Credit: Xin Zhang Ions can be transported at high speeds through a molecular structure derived from cellulose — the main constituent of plant cell walls, and the most abundant organic material on Earth1. Continued here |
27 Years Ago, Steve Jobs Explained How He Fired People. Here's How He Did It "My job has sometimes been exactly that: to get rid of some of the people that didn't measure up." Continued here |
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The Secrets of Great Teamwork Over the years, as teams have grown more diverse, dispersed, digital, and dynamic, collaboration has become more complex. But though teams face new challenges, their success still depends on a core set of fundamentals. As J. Richard Hackman, who began researching teams in the 1970s, discovered, what matters most isn’t the personalities or behavior of the team members; it’s whether a team has a compelling direction, a strong structure, and a supportive context. In their own research, Haas and Mortensen have found that teams need those three “enabling conditions” now more than ever. But their work also revealed that today’s teams are especially prone to two corrosive problems: “us versus them” thinking and incomplete information. Overcoming those pitfalls requires a new enabling condition: a shared mindset. Continued here |
The Truth About Ozempic, the ‘Secret’ Celebrity Weight Loss Drug In the north of England, Chloe books Friday afternoon off work to drive to six different pharmacies in search of her routine prescription. For a year, she’s injected Ozempic every Monday to manage her type 2 diabetes, but it’s out of stock in her area. She’s had no luck for the last four months. Instead, she’s had to switch to Trulicity, an alternative drug, which requires her to start again from its lowest prescription to build up the dose. Her blood sugar levels have oscillated for a couple of weeks, leading to fatigue and headaches, as well as requiring her to self-administer uncomfortable finger prick blood tests more frequently. Continued here |
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How to Survive a Recession and Thrive Afterward According to an analysis led by Ranjay Gulati, during the recessions of 1980, 1990, and 2000, 17% of the 4,700 public companies studied fared very badly: They went bankrupt, went private, or were acquired. But just as striking, 9% of the companies flourished, outperforming competitors by at least 10% in sales and profits growth. Continued here |
Ovarian cancer mutational processes drive site-specific immune evasion - Nature Nature (2022)Cite this article High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability1,2,3,4 patterned by distinct mutational processes5,6, tumour heterogeneity7,8,9 and intraperitoneal spread7,8,10. Immunotherapies have had limited efficacy in HGSOC11,12,13, highlighting an unmet need to assess how mutational processes and the anatomical sites of tumour foci determine the immunological states of the tumour microenvironment. Here we carried out an integrative analysis of whole-genome sequencing, single-cell RNA sequencing, digital histopathology and multiplexed immunofluorescence of 160 tumour sites from 42 treatment-naive patients with HGSOC. Homologous recombination-deficient HRD-Dup (BRCA1 mutant-like) and HRD-Del (BRCA2 mutant-like) tumours harboured inflammatory signalling and ongoing immunoediting, reflected in loss of HLA diversity and tumour infiltration with highly differentiated dysfunctional CD8+ T cells. By contrast, foldback-inversion-bearing tumours exhibited elevated immunosuppressive TGFβ signalling and immune exclusion, with predominantly naive/stem-like and memory T cells. Phenotypic state associations were specific to anatomical sites, highlighting compositional, topological and functional differences between adnexal tumours and distal peritoneal foci. Our findings implicate anatomical sites and mutational processes as determinants of evolutionary phenotypic divergence and immune resistance mechanisms in HGSOC. Our study provides a multi-omic cellular phenotype data substrate from which to develop and interpret future personalized immunotherapeutic approaches and early detection research. Continued here |
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4 Tests That Your CFO Is a Great Business Partner Your CFO should support the CEO's vision, manage costs and profitability, invest in growth, set goals and hold people accountable. Continued here |
China’s Protests Spill Into the US. FBI Arrests a Chinese Student For Stalking. A 25-year-old Chinese student was arrested and charged in U.S. federal court in Boston on Wednesday accused of harassing a Chinese pro-democracy activist. Xiaolei Wu, a student at the Berklee College of Music, was charged with one count of stalking. He was accused of sending threats to the victim through Instagram, email and Chinese social media platform WeChat, after learning through Instagram that the victim had put up a pro-democracy flier near campus in October. The flier said, “We Want Freedom”, “We Want Democracy”, and “Stand With Chinese People.” Continued here |
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Have You Been ‘Therapy-Baited’ While Dating? Here’s How to Tell Emily Wester was impressed when the guy she was on a date with opened up about having a lot of experience in therapy. They got on well, went out on more dates and the 32-year-old project manager caught feelings. Eventually they became boyfriend and girlfriend. Years into the relationship, she discovered he had a “huge coke addiction” and it became clear that he’d vastly exaggerated his experience with therapy. “He’d been referred to the NHS for six sessions and only went to about two,” she says. They carried on with their relationship, but when things became strained during lockdown, Wester - who was actually in therapy - convinced him to see a professional. “Clearly, he didn’t tell them anything, because he came back and told me, ‘Oh, they said I didn’t need therapy.’” she says. “This is a man still addicted to cocaine, who’s had a lot of childhood trauma. Nobody would have said he didn’t need therapy if he’d actually told them what was going on.” Continued here |
How the EU could force Apple to open up iMessage and end an App Store monopoly The European Union's new law could be the beginning of the end for Apple’s iMessage and App Store. Apple and other tech giants are facing even more pressure from the European Union to change their ways. According to a Bloomberg report, Apple is gearing up to allow third-party app stores onto its devices due to an upcoming law from the EU. Continued here |
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Global estimates of excess deaths from COVID-19 Enrique Acosta is at the Centre for Demographic Studies, 08193 Barcelona, Spain, and at the Max Planck Institute for Demographic Research, Rostock, Germany. Knowing how COVID-19 affects global mortality rates is crucial if we are to understand the factors that govern its spread and severity, and to be able to evaluate the effectiveness of government responses to the pandemic. In May, a team of researchers led by the World Health Organization (WHO) and the United Nations Department of Economic and Social Affairs published the first results from their attempt to estimate global, COVID-19-related death rates. Writing in Nature, Msemburi et al.1 present these estimates in more detail. Continued here |
Barbara Corcoran's 7 Top Tips for Succeeding Against All Odds She's been an icon of entrepreneurship for decades--first as a New York City real estate maven and then as a Shark. But even at 73, she still leans on some early lessons learned. Continued here |
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Are prices real? How ghosts of calculus and physics influenced what we pay for things today With inflation in the UK and around the world threatening to spiral out of control, prices of everything from milk to oil, energy and Christmas presents are a concern for most of us. Most people understand prices as simply the result of supply and demand – an agreement between sellers and buyers about how much something should cost. But there’s more to these numbers, starting with the mathematically philosophical question: do prices even exist? Continued here |
The Founder of CitiStorage's Next Billion-Dollar Idea: Disrupting College The storage company founder Norm Brodsky recently embarked on a new enterprise: teaching entrepreneurs how to scale up. Here's what you can learn from the octogenarian. Continued here |
Buying gifts? Why ‘buy now, pay later’ could be a dangerous option for many holiday shoppers Gift-givers hoping to splurge this holiday season despite the pinch of high inflation have an easy option: buy now, pay later. An ever-growing number of financial companies and apps are offering consumers what are essentially small, short-term loans that combine instant gratification with interest- and fee-free payments spread out in the new year. Continued here |
The Perfect Paradox of Star Brands: An Interview with Bernard Arnault of LVMH Who would want to run a company that makes and sells products no one needs? Only a fool, right? Unless, of course, the company is LVMH Moët Hennessy Louis Vuitton, the world’s largest and by far most successful purveyor of luxury goods. Each year, LVMH sells billions of dollars—$10 billion in 2000 to be exact—of items that serve little purpose in the lives of consumers except to fulfill dreams. And those dreams don’t come cheap—a magnum of 1985 Dom Pérignon Rosé champagne costs about $925; a Givenchy gown $15,000; and the finest TAG Heuer watch upwards of $58,000. No one needs these items, of course, yet millions desire them. Continued here |
As viral infections skyrocket, masks are still a tried-and-true way to help keep yourself and others safe The cold and flu season of 2022 has begun with a vengeance. Viruses that have been unusually scarce over the past three years are reappearing at remarkably high levels, sparking a “tripledemic” of COVID-19, the flu and respiratory syncytial virus, or RSV. This November’s national hospitalization levels for influenza were the highest in 10 years. To respond to the COVID-19 pandemic, we and our public health colleagues have had to quickly revive and apply decades of evidence on respiratory virus transmission to chart a path forward. Over the course of the pandemic, epidemiologists have established with new certainty the fact that one of our oldest methods for controlling respiratory viruses, the face mask, remains one of the most effective tools in a pandemic. Continued here |
The Inside Story of Europe’s Weirdest Crypto Mining Boom MITROVICA, Kosovo – There are divided cities all over the world. Some are separated by walls, some by armed checkpoints but a lot are just separated by fear and mistrust. In Mitrovica in the north of Kosovo, Europe’s newest country, the symbol and literal representation of division is a bridge. The optimistically named New Bridge that crosses the River Ibar separates less than 40,000 Serbs from the rest of Albanian Kosovo, and its government, law enforcement, courts, energy bills, and, most recently, licence plate requirements. Continued here |
1.5°C: where the target came from – and why we're losing sight of its importance The US economist William Nordhaus claimed as early as the 1970s, when scientific understanding of climate change was still taking shape, that warming of more than 2°C would “push global conditions past any point that any human civilisation had experienced”. By 1990, scientists had also weighed in: 2°C above the pre-industrial average was the point at which the risk of unpredictable and extensive damage would rapidly increase. Two years later, the United Nations Framework Convention on Climate Change (UNFCCC) was established to stabilise the amount of greenhouse gas in the atmosphere at a level that would “prevent dangerous interference with the climate system”. At the first summit in Berlin in 1995, countries began negotiations for the global response to climate change which continue to this day. Continued here |
Emotionally Intelligent People Don’t Do Small Talk. Here’s What They Do Instead Want to be more emotionally intelligent? Learn how to engage in smart conversation--the type that helps you stronger relationships. Continued here |
ANC in crisis: South Africa's governing party is fighting to stay relevant - 5 essential reads Director, African Centre for the Study of the United States, University of Pretoria South Africa’s governing party, the African National Congress (ANC), is in a crisis. Having dominated the country’s politics since democracy in 1994, it has been losing voter support in the last three national elections. Since the 2016 local elections2016 local elections, the party has also been losing some of its strongholds. Continued here |
Air purifiers: indoor pollution kills but many devices are ineffective and some may even cause harm Air pollution kills around 7 million people each year. Most of these deaths occur in developing countries, where solid fuel is often burned in poorly ventilated spaces. However, between 26,000 and 38,000 of those deaths occur in the UK. People in the UK spend over 80% of their time indoors, whether at home, at work, at school or commuting. So making sure the air inside those enclosed spaces is safe to breathe is crucial. Continued here |
Advent Calendars: How Small Businesses Are Reinvigorating the Christmas Tradition Advent calendars have increased in popularity over recent years; here's how businesses say they've helped to bolster their holiday sales. Continued here |
Best space images of 2022: 10 stellar views of the universe In 2022, we saw some of the most striking photos from deep space alongside brand-new views of our Solar System. Historically important, scientifically informative, or just plain beautiful, the year was full of remarkable space images. Continued here |
Google’s CEO Faced Intense Criticism at an All-Hands Meeting. His Response Was a Lesson for Every Leader No one can predict the future, but that doesn't mean you can't provide your employees with certainty. Continued here |
Why This Investor Put Her Money on ClassPass's Payal KadaÂkia Anjula Achariahas invested in several successful startups. Here's how you can get her attention. Continued here |
Teen Survivor of South Korea Crowd Crush Found Dead in Suspected Suicide A teenager who survived a deadly crowd crush in Seoul over Halloween weekend was found dead on Tuesday night, local news reported. A police official said he is suspected to have died by suicide, though this remains unconfirmed. According to the South Korean police, the unnamed high schooler was found in a motel located in western Seoul, following a missing person’s report by his mother. No suicide note was found. Continued here |
How Leaders Can Open Up to Their Teams Without Oversharing
In the age of social sharing, people who work together know more and more about each other. In general, this is a good thing. Research shows our brains respond positively to people when we feel a personal connection with them. Command and control management is on its way out, and bosses who practice empathy and make an effort to connect are in. But, when leaders open up too much to their teams, they can also completely undermine themselves. So, when does sharing become oversharing? This issue often presents itself when there are new initiatives or changes in an organization, and leaders aren’t sure how much of their worries they should reveal. The best leaders are honest about how they feel while simultaneously presenting a clear path forward. This is called being selectively vulnerable — or opening up while still prioritizing everyone’s boundaries. A good rule of thumb for figuring out if you’re about to overshare is to ask yourself: “How would I feel if my manager said this to me?” If it’s something that you’d be thankful to hear, chances are, your reports will feel similarly. On the other hand, if you think members of your team might be feeling anxious about the project, it’s okay to surface those feelings to help them feel less isolated. Always try to pair realism with optimism, and share when you sense it will be helpful to others. Continued here
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